Ammonia → Benzo[b]thiophene-3-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

HRID 599195

反応式

HRID 599195 の反応式
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[C:15]([C:22](O)=[O:23])=[CH:14]1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:22]([C:15]3[C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[S:13][CH:14]=3)=[O:23])[CH2:3]1)[CH2:9]2

参加物

4

反応物 3

HCID 222AmmoniaHCID 601280Benzo(b)thiophene-3-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

生成物 1

HCID 67152137Benzo[b]thiophene-3-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

実験手順

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 1-benzothiophene-3-carboxylic acid (Maybridge) according to methods A and C; yield 60 mg, 0.17 mmol (56%): 1H NMR (300 MHz, methanol-d4) δ 2.10-2.30 (m, 5H), 2.48 (s, 2H), 3.50 (d, J=13 Hz, 2H), 3.56 (s, 2H), 3.83 (d, J=13 Hz, 2H), 4.33 (s, 1H), 7.36-7.49 (m, 2H), 7.91-7.96 (m, 1H), 8.28-8.34 (m, 2H); MS (DCI/NH3) m/z 313 (M+H)+; Anal. C18H20N2OS.HCl.0.17H2O: C, H, N.

出典と根拠

ORDレコード
ord-393f60447c354868addbeb95f0cd1b64
出典データセット
uspto-grants-2011_03
特許番号
US07897766B2

関連ノート

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