Bromine → HCID 118235372、化合物
反応式
[F:1][C:2]1[CH:8]=[C:7]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].CC([O-])=O.[K+].[Br:18]Br>CC(O)=O>[Br:18][C:5]1[CH:6]=[C:7]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:8]=[C:2]([F:1])[C:3]=1[NH2:4]参加物
5
実験手順
A mixture of 2-fluoro-4-methylsulfonyl-aniline (22.76 mmol) and KOAc (22.7 mmol) in AcOH was stirred at room temperature. The mixture was cooled to 0° C. and Br2 (22.7 mmol) was added dropwise. The mixture was stirred for 30 min at 0° C. The mixture was concentrated and the residue was taken up in EtOAc. The organic mixture was washed (sat. NaHCO3, sat. Na2S2O3), dried (Na2SO4) and concentrated to yield the desired product.
後処理
- temperatureThe mixture was cooled to 0° C.
- stirringThe mixture was stirred for 30 min at 0° C
- concentrationThe mixture was concentrated
- washThe organic mixture was washed (sat. NaHCO3, sat. Na2S2O3)
- dry with materialdried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-81cfec79e52b4362b6f58408b9c46861
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440929B2
反応ノート
読み込み中…