Sodium Iodide → 2-(2-(2-Iodoethoxy)ethoxy)ethanol
反応式
Cl[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[I-:11].[Na+].C(=O)([O-])O.[Na+]>CC(C)=O>[I:11][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10]参加物
5
実験手順
A 25 ml reaction flask, equipped with a reflux condenser, an oil bath and a magnetic stirrer was charged with 2 g (11.9 mmol) of 2-[2-(2-chloroethoxy)-ethoxy]-ethanol (Fluka), 4 g of sodium iodide and 3 g of sodium hydrogencarbonate in 20 ml of Acetone. The reaction mixture is refluxed over night and when cold, filtered. The filtrate is concentrated at the rotavap, dissolved in 5 ml of CH2Cl2 and filtered again. Then the filtrate is concentrated again at the rotavap to yield 2.5 g of a yellow oil. The NMR shows a pure substance (CDCl3) 2.58 s broad (1H/OH); 3.22 t (2H/CH2-J); 3.53-3.77 m (10H/CH2—O).
後処理
- customA 25 ml reaction flask
- customequipped with a reflux condenser, an oil bath and a magnetic stirrer
- temperatureThe reaction mixture is refluxed over night
- filtrationwhen cold, filtered
- concentrationThe filtrate is concentrated at the rotavap
- dissolutiondissolved in 5 ml of CH2Cl2
- filtrationfiltered again
- concentrationThen the filtrate is concentrated again at the rotavap
出典と根拠
- ORDレコード
- ord-33165b966d6b4ae18e589dde0532ab86
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897779B2
反応ノート
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