Ammonium Chloride → 6-Bromo-4-methylpyridin-3-amine

HRID 59940

反応式

HRID 59940 の反応式
[NH4+].[Cl-].[Br:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([N+:11]([O-])=O)=[CH:6][N:5]=1>O.[Fe]>[Br:3][C:4]1[N:5]=[CH:6][C:7]([NH2:11])=[C:8]([CH3:10])[CH:9]=1

参加物

5

反応物 2

HCID 25517Ammonium ChlorideHCID 3458732-Bromo-4-methyl-5-nitropyridine

生成物 1

HCID 199260946-Bromo-4-methylpyridin-3-amine

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

A mixture of NH4Cl (14.9 mmol) and iron powder (18.4 mmol) in H2O (5 mL) was stirred at 90° C. 2-bromo-4-methyl-5-nitropyridine (2.3 mmol) was added in portions. The mixture was stirred at 90° C. for 1 h and 15 min. The reaction was stopped and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.

後処理

  1. stirringThe mixture was stirred at 90° C. for 1 h and 15 min
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried (Na2SO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-25b06232104b4fb280ad8f917456b77e
出典データセット
uspto-grants-2016_09
特許番号
US09440929B2

関連ノート

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