Chlorosuccinimide → 4-Amino-3-chloro-5-fluorobenzonitrile

HRID 59941

反応式

HRID 59941 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[F:10].C1C(=O)N([Cl:18])C(=O)C1>CC(O)=O>[NH2:1][C:2]1[C:3]([F:10])=[CH:4][C:5]([C:6]#[N:7])=[CH:8][C:9]=1[Cl:18]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 27564314-Amino-3-fluorobenzonitrile

生成物 1

HCID 680399954-Amino-3-chloro-5-fluorobenzonitrile

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
70 °C

実験手順

A mixture of 4-amino-3-fluorobenzonitrile (184 mmol) and NCS (276 mmol) in AcOH (300 mL) was stirred at 70° C. for approximately 16 h. The mixture was concentrated. H2O was added to the residue and the solid product was filtered off and washed (sat. NaHCO3 and H2O). To eliminate H2O, THF was added and removed under reduced pressure to yield the desired product.

後処理

  1. concentrationThe mixture was concentrated
  2. additionH2O was added to the residue
  3. filtrationthe solid product was filtered off
  4. washwashed (sat. NaHCO3 and H2O)
  5. additionwas added
  6. customremoved under reduced pressure

出典と根拠

ORDレコード
ord-306095c73a9a4bfabc97bcd9d3ba38ab
出典データセット
uspto-grants-2016_09
特許番号
US09440929B2

関連ノート

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