Hydrochloric Acid → 1-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

HRID 599579ノート

反応式

HRID 599579 の反応式
[ClH:1].C(OC(=O)[NH:8][N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]2[CH:20]=[C:19]([F:21])[C:18]([F:22])=[C:17]([F:23])[CH:16]=2)[C:10]1=[O:24])(C)(C)C>C(OCC)(=O)C.C(Cl)(Cl)Cl>[ClH:1].[NH2:8][N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]2[CH:16]=[C:17]([F:23])[C:18]([F:22])=[C:19]([F:21])[CH:20]=2)[C:10]1=[O:24]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86628505Tert-butyl[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate

生成物 1

HCID 668393791-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 4 N hydrochloric acid in ethyl acetate (1 mL) was added to a solution of tert-butyl[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate (134 mg) in chloroform (1 mL), and the reaction solution was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to obtain 109 mg of the title compound. The property value of the compound is as follows.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f529bf749fca49e39ded511492113bea
出典データセット
uspto-grants-2011_03
特許番号
US07897632B2

反応ノート

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