Diisopropylethylamine → 2-[4-chloro-1-(4-chlorophenyl)butyl]-5-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}[1,3,4]oxadiazole

IPEA (2.5 mL), 5-chloro-2-(4-chlorophenyl)pentanoic acid (430 mg) and BOPCl (0.44 g) were added to a suspension of (E)-3-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]acrylic acid hydrazide dihydrochloride (500 mg) in methylene chloride (15 mL) at room temperature, and the reaction solution was stirred at room temperature for 14 hours. Water was added to the reaction solution, followed by extraction with chloroform. The resulting extract was washed with a saturated sodium chloride solution, dried over magnesium sulfate and then concentrated under reduced pressure. A solution of the residue in phosphorus oxychloride (4 mL) was heated under reflux for five hours. The reaction solution was left to cool to room temperature and concentrated under reduced pressure. A saturated sodium bicarbonate solution was added to the resulting residue, followed by extraction with chloroform. The resulting extract was dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: heptane-ethyl acetate system) to obtain 366 mg of the title compound. The property value of the compound is as follows.

1. extractionfollowed by extraction with chloroform
2. extractionThe resulting extract
3. washwas washed with a saturated sodium chloride solution
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. temperatureA solution of the residue in phosphorus oxychloride (4 mL) was heated
7. temperatureunder reflux for five hours
8. waitThe reaction solution was left
9. temperatureto cool to room temperature
10. concentrationconcentrated under reduced pressure
11. additionA saturated sodium bicarbonate solution was added to the resulting residue
12. extractionfollowed by extraction with chloroform
13. extractionThe resulting extract
14. dry with materialwas dried over magnesium sulfate
15. concentrationconcentrated under reduced pressure
16. customThe residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: heptane-ethyl acetate system)

ORDレコード

ord-4a807abf44c847f6bf59e74de514f15c

出典データセット

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07897632B2