[5-(Trifluoromethyl)pyridin-2-yl]methanamine → 4-(((5-(Trifluoromethyl)pyridin-2-yl)methyl)amino)benzo[d][1,2,3]triazine-8-carboxamide

HRID 59966

反応式

HRID 59966 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[CH:5][C:6]([CH2:9][NH2:10])=[N:7][CH:8]=1.O[C:14]1[C:15]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([NH2:26])=[O:25])[C:16]=2[N:17]=[N:18][N:19]=1>>[F:12][C:2]([F:11])([F:1])[C:3]1[CH:4]=[CH:5][C:6]([CH2:9][NH:10][C:14]2[C:15]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([NH2:26])=[O:25])[C:16]=3[N:17]=[N:18][N:19]=2)=[N:7][CH:8]=1

参加物

3

反応物 2

HCID 3796375[5-(Trifluoromethyl)pyridin-2-yl]methanamineHCID 1785136134-oxo-1H-1,2,3-benzotriazine-8-carboxamide

生成物 1

HCID 760735784-(((5-(Trifluoromethyl)pyridin-2-yl)methyl)amino)benzo[d][1,2,3]triazine-8-carboxamide

実験手順

Compound 7 was prepared following general synthetic scheme 7 wherein (5-(trifluoromethyl)-pyridin-2-yl)methanamine was reacted with 4-hydroxybenzo[d][1,2,3]-triazine-8-carboxamide to give the title compound. LC-MS [349 (M+1)], 1H NMR (400 MHz, DMSO-d): δ 9.50 (t, 1H), 9.35 (s, 1H), 8.93 (s, 1H), 8.55 (d, 2H), 8.16 (dd, 1H), 8.05-8.01 (m, 2H), 7.65 (d, 1H), 5.07 (d, 2H).

後処理

  1. customCompound 7 was prepared

出典と根拠

ORDレコード
ord-143ee002a12e4c7091af4fc0d04bc553
出典データセット
uspto-grants-2016_09
特許番号
US09440968B2

関連ノート

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