4-(4-Benzylpiperazin-1-yl)-1lambda6-thiane-1,1-dione → 1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)piperazine

HRID 599728ノート

反応式

HRID 599728 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:19][CH2:18][S:17](=[O:21])(=[O:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[O:21]=[S:17]1(=[O:20])[CH2:16][CH2:15][CH:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:19][CH2:18]1

参加物

5

反応物 2

HCID 672737414-(4-Benzylpiperazin-1-yl)-1lambda6-thiane-1,1-dioneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 467858481-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)piperazine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of 0.57 g (1.85 mmol) 1-benzyl-4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-piperazine and 300 mg 10% Pd/C in 30 mL MeOH was hydrogenated at 50° C. and 50 psi hydrogen pressure for 10 h. The catalyst was removed by suction filtering and the filtrate was concentrated by evaporation i. vac. The product was reacted further without purification.

後処理

  1. customwas hydrogenated at 50° C.
  2. customThe catalyst was removed by suction
  3. filtrationfiltering
  4. concentrationthe filtrate was concentrated by evaporation i
  5. customThe product was reacted further without purification

出典と根拠

ORDレコード
ord-43f4e1a5a2ed4b30926e2096083b608d
出典データセット
uspto-grants-2011_03
特許番号
US07897603B2

反応ノート

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