関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Benzoxazolinone, 5-bromo- | HCID 26853 | — |
| 反応物 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5-Bromo-3-(2-methoxyethyl)benzo[d]oxazol-2(3H)-one | HCID 57999690 | — |
反応手順
A mixture of 5-bromobenzo[d]oxazol-2(3H)-one (2.06 g), 1-bromo-2-methoxyethane (1.085 mL) and potassium carbonate (3.99 g) in acetonitrile (15 mL) was heated at 60° C. for 16 h. Water was added and the mixture was extracted with ethyl acetate (3 times). The organic layers were dried over magnesium sulfate, evaporated and purified by flash silica chromatography eluting with 5:1 isohexane/acetone to give the subtitle compound (1.359 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07902181B2 |
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| 出典データセット | uspto-grants-2011_03 |
|---|
| ORD ID | ord-f266f099fe2b4d08929103f9150f70a2 |
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| 出典メモ | uspto-grants-2011_03 |
|---|
