反应详情

温度

60 °C

A mixture of 5-bromobenzo[d]oxazol-2(3H)-one (2.06 g), 1-bromo-2-methoxyethane (1.085 mL) and potassium carbonate (3.99 g) in acetonitrile (15 mL) was heated at 60° C. for 16 h. Water was added and the mixture was extracted with ethyl acetate (3 times). The organic layers were dried over magnesium sulfate, evaporated and purified by flash silica chromatography eluting with 5:1 isohexane/acetone to give the subtitle compound (1.359 g).

1. extractionthe mixture was extracted with ethyl acetate (3 times)
2. dry with materialThe organic layers were dried over magnesium sulfate
3. customevaporated
4. custompurified by flash silica chromatography
5. washeluting with 5:1 isohexane/acetone