Sodium Sulfite → Sodium (2-methylthiazol-4-yl)methanesulfonate

HRID 60045

反応式

HRID 60045 の反応式
Cl[CH2:2][C:3]1[N:4]=[C:5]([CH3:8])[S:6][CH:7]=1.[S:9]([O-:12])([O-:11])=[O:10].[Na+:13].[Na+]>O>[CH3:8][C:5]1[S:6][CH:7]=[C:3]([CH2:2][S:9]([O-:12])(=[O:11])=[O:10])[N:4]=1.[Na+:13]

参加物

4

反応物 2

HCID 24437Sodium SulfiteHCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazole

生成物 1

HCID 59464713Sodium (2-methylthiazol-4-yl)methanesulfonate収率 101.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

4-Chloromethyl-2-methylthiazole (250 mg, 1.69 mmol) is dissolved in H2O (2 mL) and treated with sodium sulfite (224 mg, 1.78 mmol). The reaction mixture is subjected to microwave irradiation for 20 minutes at 200° C. The reaction mixture is diluted with H2O (30 mL) and washed with EtOAc (2×25 mL). The aqueous layer is concentrated to afford 0.368 g of the desired product as a yellow solid. LC/MS ESI+ 194 (M+1, free acid).

後処理

  1. customirradiation for 20 minutes at 200° C
  2. washwashed with EtOAc (2×25 mL)
  3. concentrationThe aqueous layer is concentrated

出典と根拠

ORDレコード
ord-2dee5aeb32ce49538fa9567ca188082d
出典データセット
uspto-grants-2016_09
特許番号
US09440963B2

関連ノート

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