Toluene → Methyl 3-amino-3-methylbutanoate

HRID 600915ノート

反応式

HRID 600915 の反応式
[NH2:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].S(Cl)(Cl)=O.[C:13]1(C)C=CC=CC=1>CO>[NH2:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4]([O:6][CH3:13])=[O:5]

参加物

5

反応物 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 27609333-Amino-3-methylbutanoic acid

生成物 1

HCID 18667677Methyl 3-amino-3-methylbutanoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 3-amino-3-methyl-butyric acid 10-1 (1 eq.) in methanol at 0° C. was added 2 eq. of thionyl chloride. The reaction mixture was warmed to room temperature and stirred overnight. The solvent was evaporated to give azeotropic mixture of 10-2 and toluene (x=3) which was used for Step B. MS: MH+=132.1

後処理

  1. customThe solvent was evaporated
  2. customto give azeotropic

出典と根拠

ORDレコード
ord-bb6106fff1594252865d9d33fdecda9a
出典データセット
uspto-grants-2011_03
特許番号
US07902240B2

反応ノート

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