Hydrochloric Acid → 2-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-amine hydrochloride

HRID 60121ノート

反応式

HRID 60121 の反応式
[ClH:1].Cl.[C:3]1([C:9]2[N:10]=[C:11]3[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][N:12]3[CH:18]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H][H]>[Pt](=O)=O.CO>[ClH:1].[C:3]1([C:9]2[N:10]=[C:11]3[CH2:16][CH:15]([NH2:17])[CH2:14][CH2:13][N:12]3[CH:18]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 117776411HCID 117776411、化合物HCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 1055088122-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-amine hydrochloride

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒2 回HCID 887Methanol溶媒

実験手順

Concentrated hydrochloric acid (0.11 ml) and platinum(IV) dioxide (83 mg) were added to a methanol (183 ml) solution of 2-phenylimidazo[1,2-a]pyridin-7-amine hydrochloride (900 mg), and the obtained mixture was then stirred in a hydrogen atmosphere for 4 hours. Thereafter, platinum(IV) dioxide (83 mg) was added to the reaction solution, and the obtained mixture was further stirred in a hydrogen atmosphere for 14 hours 30 minutes. Thereafter, the reaction solution was filtered with Celite, and was then washed with methanol (15 ml). The filtrate was concentrated under reduced pressure, and diethyl ether (3.6 ml) was then added to the obtained residue to solidify it, so as to obtain the title compound (733 mg) in the form of a gray solid.

後処理

  1. filtrationThereafter, the reaction solution was filtered with Celite
  2. washwas then washed with methanol (15 ml)
  3. concentrationThe filtrate was concentrated under reduced pressure, and diethyl ether (3.6 ml)
  4. additionwas then added to the obtained residue

出典と根拠

ORDレコード
ord-480260704a6f45fbabc33017c1e0094c
出典データセット
uspto-grants-2016_09
特許番号
US09440970B2

反応ノート

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