Bromopentafluorobenzene → 4-Nitro-2',3',4',5',6'-pentafluorobiphenyl

HRID 601452

反応式

HRID 601452 の反応式
I[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.Br[C:12]1[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([F:21])[C:13]=1[F:22]>[Cu]>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([C:12]2[C:13]([F:22])=[C:14]([F:21])[C:15]([F:20])=[C:16]([F:19])[C:17]=2[F:18])=[CH:3][CH:4]=1)([O-:10])=[O:9]

参加物

4

反応物 2

HCID 9578BromopentafluorobenzeneHCID 124951-Iodo-4-nitrobenzene

生成物 1

HCID 112547604-Nitro-2',3',4',5',6'-pentafluorobiphenyl収率 63.4%

試薬・触媒・溶媒 1

HCID 23978Copper触媒

反応条件

温度
190 °C

実験手順

A mixture of 4-iodonitrobenzene (15 g, 0.060 mol), bromopentafluorobenzene (14.9 g, 2.56 mL, 0.060 mol) and copper powder (30 g) was placed into a 50-mL J-Young glass tube and heated at 190° C. for 24 hours. The tube was cooled and the mixture was extracted exhaustively with dichloromethane. The solvent was removed and the residue was extracted with boiling hexane and filtered while hot. The solvent was removed and the resulting viscous solid was sublimed to obtain 4-nitro-2′,3′,4′,5′,6′-pentafluorobiphenyl as a yellow solid (11.0 g, 63% yield).

後処理

  1. customwas placed into a 50-mL J-Young glass tube
  2. temperatureThe tube was cooled
  3. extractionthe mixture was extracted exhaustively with dichloromethane
  4. customThe solvent was removed
  5. extractionthe residue was extracted with boiling hexane
  6. filtrationfiltered while hot
  7. customThe solvent was removed

出典と根拠

ORDレコード
ord-adca81a513a1436a87ff1d0673b1d03f
出典データセット
uspto-grants-2011_03
特許番号
US07902363B2

関連ノート

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