4-Nitro-2',3',4',5',6'-pentafluorobiphenyl → 2',3',4',5',6'-Pentafluoro[1,1'-biphenyl]-4-ylamine
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([F:16])=[C:14]([F:17])[C:13]([F:18])=[C:12]([F:19])[C:11]=2[F:20])=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([F:20])=[C:12]([F:19])[C:13]([F:18])=[C:14]([F:17])[C:15]=2[F:16])=[CH:6][CH:5]=1参加物
4
実験手順
4-Nitro-2′,3′,4′,5′,6′-pentafluorobiphenyl (10 g, 0.0345 mol) was dissolved in absolute ethanol (750 mL) and stirred under a hydrogen atmosphere (1 atm.) over Pd/C (0.3 g) until absorption of hydrogen ceased. The solution was filtered and the solvent was removed. The crude product was purified by column chromatography to give 4-amino-2′,3′,4′,5′,6′-pentafluorobiphenyl as a white powder (8.0 g, 89% yield).
後処理
- customuntil absorption of hydrogen
- filtrationThe solution was filtered
- customthe solvent was removed
- customThe crude product was purified by column chromatography
出典と根拠
- ORDレコード
- ord-97dcab5c1bf14561aeaaafe6f4e18302
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07902363B2
反応ノート
読み込み中…