Chlorosulfonic acid → 2-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

HRID 601614ノート

反応式

HRID 601614 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=1>>[F:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][C:14](=[O:16])[CH3:15])=[CH:11][C:12]=1[S:2]([Cl:1])(=[O:5])=[O:3]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 521187(4-Fluorophenyl)acetone

生成物 1

HCID 858617322-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

実験手順

To a stirred flask of chlorosulphonic acid (344 g, 2.96 mol) cooled to −10° C. is added dropwise 1-(4-fluoro-phenyl)-propan-2-one (10 g, 65 mmol). The reaction mixture is left stirring at room temperature overnight and then poured carefully onto ice. The resultant solution is extracted with ethyl acetate and the organic extracts combined, dried (MgSO4) and concentrated in vacuo to yield the titled compound.

後処理

  1. waitThe reaction mixture is left
  2. additionpoured carefully onto ice
  3. extractionThe resultant solution is extracted with ethyl acetate
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2829276b9dfd4f709ad209f0573e4351
出典データセット
uspto-grants-2011_03
特許番号
US07902375B2

反応ノート

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