Sodium Sulfite → 2-Fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt

HRID 601615ノート

反応式

HRID 601615 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[S:12](Cl)(=[O:14])=[O:13].S([O-])([O-])=O.[Na+:20].[Na+].C(=O)([O-])O.[Na+]>O1CCOCC1.O>[Na+:20].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[S:12]([O-:14])=[O:13]

参加物

6

反応物 3

HCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 858617322-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

生成物 1

HCID 671597242-Fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
70 °C

実験手順

To a stirred solution of 2-fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride (AG1) (16.25 g, 86.36 mmol) in dioxane (200 ml) is added dropwise a solution of sodium sulfite (16.38 g, 130 mmol) and sodium hydrogen carbonate (10.92 g, 130 mmol) in water (200 ml). The reaction mixture is heated to 70° C. for 20 minutes and then allowed to cool to room temperature. The solvent is removed in vacuo and the resultant residue is used crude in the next step.

後処理

  1. temperatureto cool to room temperature
  2. customThe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-ae99693c83e746f596f9960fb0895181
出典データセット
uspto-grants-2011_03
特許番号
US07902375B2

反応ノート

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