Methyl iodide → 1-(4-Fluoro-3-methanesulfonyl-phenyl)-propan-2-one

HRID 601616ノート

反応式

HRID 601616 の反応式
[Na+].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=[O:12])[CH3:11])=[CH:5][C:4]=1[S:13]([O-:15])=[O:14].[CH3:16]I>CN(C=O)C>[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=[O:12])[CH3:11])=[CH:5][C:4]=1[S:13]([CH3:16])(=[O:15])=[O:14]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 671597242-Fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt

生成物 1

HCID 574668151-(4-Fluoro-3-methanesulfonyl-phenyl)-propan-2-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution comprising 2-fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt (AG2) (15.43 g, 64.83 mmol) in DMF (300 ml) is treated with methyl iodide (18.45 g, 130 mmol). The reaction mixture is stirred at room temperature for 30 minutes. Purification is carried out by chromatography on silica (eluting with 4:1 hexane-ethyl acetate) to afford the titled compound.

後処理

  1. customPurification

出典と根拠

ORDレコード
ord-f261ee5e44774a379824232bcd7ff4dd
出典データセット
uspto-grants-2011_03
特許番号
US07902375B2

反応ノート

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