Trifluoroacetic acid → Trifluoroacetic acid

反応式

C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:16])[NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])(C)(C)C.[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21]>>[NH2:7][CH2:8][CH2:9][C:10]([NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:16].[C:20]([OH:22])([C:19]([F:24])([F:23])[F:18])=[O:21]

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 25239132HCID 25239132、化合物

生成物 2

HCID 6422Trifluoroacetic acid

HCID 16782159HCID 16782159、化合物

実験手順

(2-tert-Butylcarbamoyl-ethyl)-carbamic acid tert-butyl ester (0.65 g, 2.64 mmol) is dissolved in trifluoroacetic acid (3.5 ml) and allowed to stir at room temperature under an inert atmosphere for 3 hours. The solvent is removed in vacuo to yield the titled compound as a TFA salt which is used crude in the next step: