trans-3,5-Difluorocinnamic acid → 3-(3,5-Difluorophenyl)propionic acid

HRID 601706

反応式

HRID 601706 の反応式
[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1>[Pd].C(OCC)(=O)C.C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1

参加物

5

反応物 1

HCID 5374941trans-3,5-Difluorocinnamic acid

生成物 1

HCID 36694983-(3,5-Difluorophenyl)propionic acid収率 99%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To palladium on activated charcoal (10 wt %, 2.5 g) was added a solution of (E)-3-(3,5-difluorophenyl)acrylic acid (25 g) in a mixture of ethyl acetate (100 mL) and ethyl alcohol (400 mL). The mixture was put on hydrogenator on 50 psi for 6 h. The catalyst was filtered and the solvent was removed to give 25.0 g the title compound (99% yield): 1H NMR (CDCl3, 500 MHz) δ 2.67 (2H, t, J=10 Hz), 2.93 (2H, t, J=10 Hz), 6.65 (1H, m), 6.72 (2H, m).

後処理

  1. filtrationThe catalyst was filtered
  2. customthe solvent was removed

出典と根拠

ORDレコード
ord-9bcada9b9e39424d88d9fb37f030a313
出典データセット
uspto-grants-2011_03
特許番号
US07902218B2

関連ノート

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