Sodium Hydroxide → 3,5-Difluoro-4-(2-propynyloxy)benzoic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([F:18])[C:13]=1[O:14][CH2:15][C:16]#[CH:17])[C:5]([O:7]CC#C)=[O:6].[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([F:18])[C:13]=1[O:14][CH2:15][C:16]#[CH:17])[C:5]([OH:7])=[O:6]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To 10 ml of ethanol were added 2.2 g of 2-propynyl 3,5-difluoro-4-(2-propynyloxy)benzoate and 6 ml of 15% aqueous sodium hydroxide solution, and the mixture obtained was stirred at 50° C. for 1 hour. Then, the reaction mixture was concentrated under reduced pressure. Hydrochloric acid was added to the residue for acidification. Crystals precipitated were collected by filtration and dried to obtain 1.8 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid.
後処理
- customthe mixture obtained
- concentrationThen, the reaction mixture was concentrated under reduced pressure
- additionHydrochloric acid was added to the residue for acidification
- customCrystals precipitated
- filtrationwere collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-34d0e5df0bac46a7a9a9cf4c7541ea87
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07902400B2
反応ノート
読み込み中…