1-(Benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidine → Tert-butyl-dimethyl-(3-piperidylmethoxy)silane

HRID 602124ノート

反応式

HRID 602124 の反応式
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([CH2:17][O:18][Si:19]([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20])[CH2:12]1)=O)C1C=CC=CC=1.[H][H]>[Pd].CO>[Si:19]([O:18][CH2:17][CH:13]1[CH2:14][CH2:15][CH2:16][NH:11][CH2:12]1)([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20]

参加物

5

反応物 2

HCID 589926311-(Benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 58992622Tert-butyl-dimethyl-(3-piperidylmethoxy)silane収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% palladium on activated carbon (1.32 g) was added to 1-(benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidine (13.2 g, 36.3 mmol) in methanol (130 mL). The mixture was stirred at room temperature for 1 hour in a hydrogen atmosphere. Subsequently, the mixture was filtered through Celite, followed by evaporation of the solvent to give 7.96 g (96%) of the desired compound as a colorless oil.

後処理

  1. filtrationSubsequently, the mixture was filtered through Celite
  2. customfollowed by evaporation of the solvent

出典と根拠

ORDレコード
ord-0b0a62a655e34190b0f76ee0e67e51cb
出典データセット
uspto-grants-2011_03
特許番号
US07902367B2

反応ノート

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