Guanidine Hydrochloride → 4-Pyrimidinecarboxylic acid, 2-amino-, methyl ester
反応式
C(N(CC)CC)C.C(O[CH:13]=[CH:14][C:15](=O)[C:16]([O:18][CH3:19])=[O:17])CCC.Cl.[NH2:22][C:23]([NH2:25])=[NH:24]>C(#N)CC>[NH2:25][C:23]1[N:24]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[CH:14]=[CH:13][N:22]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
Triethylamine (29 mL, 210 mmol) was added to a suspension of methyl 4-butoxy-2-oxo-3-butenate (37 g, 200 mmol, JP-A-2003-89690) and guanidine hydrochloride (23 g, 240 mmol) in propionitrile (50 mL), and the mixture was stirred for 4 hours at 100° C. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give 18 g as the mixture of the title Reference Compound and the butyl ester form of the title Reference compound as a gray-white solid (Yield: 60%).
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe residue was purified by silica gel column chromatography
- customto give 18 g
- additionas the mixture of the title Reference Compound
出典と根拠
- ORDレコード
- ord-75d1a1db9a334ec6b2d8775becfed182
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07906511B2
反応ノート
読み込み中…