Ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate → 4-(3-Oxomorpholin-4-yl)phenylacetic acid

HRID 602347ノート

反応式

HRID 602347 の反応式
[O:1]=[C:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=1>[OH-].[Na+].C(O)C>[O:1]=[C:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:9]=[CH:10][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:12][CH:13]=1

参加物

4

反応物 1

HCID 58691263Ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate

生成物 1

HCID 586912414-(3-Oxomorpholin-4-yl)phenylacetic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

20.2 g (76.8 mmol) of ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate are dissolved in a solution of 3.37 g of sodium hydroxide in 40 ml of ethanol, and the reaction solution is stirred at room temperature for 18 hours. The reaction mixture is evaporated, and the residue is dissolved in water and acidified to a pH of 3 using 1N hydrochloric acid. The mixture is extracted with ethyl acetate, and the organic phase is dried over sodium sulfate and evaporated, giving 4-(3-oxomorpholin-4-yl)phenylacetic acid as a yellowish solid; ESI 236.

後処理

  1. customThe reaction mixture is evaporated
  2. dissolutionthe residue is dissolved in water
  3. extractionThe mixture is extracted with ethyl acetate
  4. dry with materialthe organic phase is dried over sodium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-170d3c7a97ec4276bbece135aae11fd5
出典データセット
uspto-grants-2011_03
特許番号
US07906516B2

反応ノート

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