Sodium Hydroxide → 2-(4-Fluorophenyl)pyridine-4-carboxylic acid

HRID 602382ノート

反応式

HRID 602382 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][N:17]=2)[C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1.[OH-].[Na+]>CO.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][N:17]=2)[C:11]([OH:13])=[O:12])=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 66732391Methyl 2-(4-fluorophenyl)pyridine-4-carboxylate

生成物 1

HCID 463131162-(4-Fluorophenyl)pyridine-4-carboxylic acid収率 51.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Methyl 2-(4-fluorophenyl)isonicotinate (278 mg, 1.20 mmol) was dissolved in methanol (2 mL) and the solution was added with 2 mol/L aqueous sodium hydroxide solution (2 mL, 4.0 mmol), followed by stirring at room temperature overnight. The solvent was evaporated under reduced pressure and the obtained reaction mixture was dissolved in water. The solution was washed with ethyl acetate, then was added with 1 mol/L hydrochloric acid, and the obtained crystal was collected by filtration to obtain 2-(4-fluorophenyl)isonicotinic acid (134 mg, 51%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained reaction mixture
  3. washThe solution was washed with ethyl acetate
  4. additionwas added with 1 mol/L hydrochloric acid
  5. filtrationthe obtained crystal was collected by filtration

出典と根拠

ORDレコード
ord-16046aadcd824ba8aa7e7e0bcaf64c8d
出典データセット
uspto-grants-2011_03
特許番号
US07906522B2

反応ノート

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