Ethyl 2-(5-nitropyridin-2-YL)acetate → Ethyl 2-(5-aminopyridin-2-yl)acetate

HRID 602444ノート

反応式

HRID 602444 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:8][CH:9]=1

参加物

4

反応物 1

HCID 18670679Ethyl 2-(5-nitropyridin-2-YL)acetate

生成物 1

HCID 21876034Ethyl 2-(5-aminopyridin-2-yl)acetate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

The mixture of ethyl (5-nitropyridin-2-yl)acetate (3.27 g, 15.6 mmol, step 2 of Example 1) and 5 wt. % palladium on carbon (320 mg) in methanol (25 mL) was stirred under hydrogen (1 atom) at room temperature for 4 h. The mixture was filtered through a pad of Celite washing with methanol and the filtrate was concentrated to give 2.98 g (quant.) of the title compound as a yellow oil.

後処理

  1. filtrationThe mixture was filtered through a pad of Celite
  2. washwashing with methanol
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-c7c8d2f413d64e73b51eff879cc14c5d
出典データセット
uspto-grants-2011_03
特許番号
US07906532B2

反応ノート

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