Trifluoroacetic acid → Azetidin-3-yl(3,5-difluorophenyl)methanone
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:18]=[C:19]([F:21])[CH:20]=1)[C:5]([CH:7]1[CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)=[O:6].C(O)(C(F)(F)F)=O>Cl.O1CCOCC1>[NH:9]1[CH2:10][CH:7]([C:5]([C:4]2[CH:18]=[C:19]([F:21])[CH:20]=[C:2]([F:1])[CH:3]=2)=[O:6])[CH2:8]1参加物
5
実験手順
A solution of 400 mg (1.35 mmol) of tert-butyl 3-(3,5-difluorobenzoyl)azetidine-1-carboxylate in 6 mL of HCl in dioxane (4M) and 2.5 mL of TFA was stirred for 4 h at 50° C. The reaction mixture was concentrated, and the residue was washed with hexanes/ether (1/1) to afford the title compound. Mass Spectrum: m/e=199 (M+1).
後処理
- concentrationThe reaction mixture was concentrated
- washthe residue was washed with hexanes/ether (1/1)
出典と根拠
- ORDレコード
- ord-690a8d1c6f9d4259be1f5ae100ea3c17
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07906503B2
反応ノート
読み込み中…