2-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrile → 3-Amino-2-[(2-hydroxyethyl)amino]benzonitrile

HRID 603105ノート

反応式

HRID 603105 の反応式
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[C:12]([N+:13]([O-])=O)=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8].[H][H]>[Pd].CO>[NH2:13][C:12]1[C:5]([NH:4][CH2:3][CH2:2][OH:1])=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8]

参加物

5

反応物 2

HCID 114470952-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 582984983-Amino-2-[(2-hydroxyethyl)amino]benzonitrile収率 106.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Methanol (500 ml) and Pd/activated charcoal 5% (wet, 3.45 g) are added to 2-[(2-hydroxyethyl)amino]-3-nitrobenzonitrile (69 g, 0.333 mol). The suspension is shaken in a Parr apparatus under 20 psi pressure of hydrogen for 1 hour. The mixture is then filtered on Celite and evaporated to dryness to give the desired material (62.7 g). This product is used in the next step without further purification.

後処理

  1. filtrationThe mixture is then filtered on Celite
  2. customevaporated to dryness

出典と根拠

ORDレコード
ord-7f67306454614432a8cbce8ba05e1027
出典データセット
uspto-grants-2011_03
特許番号
US07906654B2

反応ノート

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