3-Chloro-4-(trifluoromethyl)aniline → HCID 11596912、化合物

HRID 603164

反応式

HRID 603164 の反応式
[C:1](OC(OC(C)(C)C)=O)(OC(C)(C)C)=[O:2].[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[C:19]([Cl:27])[CH:18]=1.[CH3:28][N:29]1[CH2:34][CH2:33][CH2:32][CH:31]([CH2:35][N:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH2:30]1>C(Cl)(Cl)Cl.CN(C)C1C=CN=CC=1>[Cl:27][C:19]1[CH:18]=[C:17]([NH:16][C:1]([N:39]2[CH2:40][CH2:41][N:36]([CH2:35][CH:31]3[CH2:32][CH2:33][CH2:34][N:29]([CH3:28])[CH2:30]3)[CH2:37][CH2:38]2)=[O:2])[CH:22]=[CH:21][C:20]=1[C:23]([F:24])([F:25])[F:26]

参加物

6

反応物 3

HCID 679623-Chloro-4-(trifluoromethyl)anilineHCID 90495Di-tert-butyl dicarbonateHCID 27369401-[(1-Methylpiperidin-3-yl)methyl]piperazine

生成物 1

HCID 11596912HCID 11596912、化合物収率 6.7%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6212Chloroform溶媒3 回

実験手順

To a solution of di-tert-butyl dicarbonate (114.6 mg) in chloroform (2 ml) was added 4-dimethylaminopyridine (6 mg). A solution of 4-amino-2-chlorobenzotrifluoride (98.1 mg) in chloroform (2 ml) was added and the reaction mixture stirred for 20 minutes at room temperature. A solution of 1-[(1-methylpiperidin-3-yl)methyl]piperazine (98.5 mg) in chloroform (2 ml) was added and the resulting solution was stirred at reflux for 18 hours. The reaction mixture was purified by column chromatography on silica gel (20 g) using a gradient of 100% dichloromethane through to 20% methanolic ammonia in dichloromethane to give the title compound (14 mg).

後処理

  1. stirringthe resulting solution was stirred
  2. temperatureat reflux for 18 hours
  3. customThe reaction mixture was purified by column chromatography on silica gel (20 g)

出典と根拠

ORDレコード
ord-756c6bebf35b4f39a1dcfd943e37587b
出典データセット
uspto-grants-2011_03
特許番号
US07906645B2

関連ノート

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