Pyridine → HCID 57656788、化合物

HRID 603168

反応式

HRID 603168 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[C:4]([Cl:12])[CH:3]=1.N1C=CC=CC=1.[Cl:19][C:20]([Cl:25])([Cl:24])[C:21](Cl)=[O:22]>ClCCl>[Cl:19][C:20]([Cl:25])([Cl:24])[C:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[C:4]([Cl:12])[CH:3]=1)=[O:22]

参加物

5

反応物 3

HCID 1049PyridineHCID 6420Trichloroacetyl chlorideHCID 679623-Chloro-4-(trifluoromethyl)aniline

生成物 1

HCID 57656788HCID 57656788、化合物収率 69%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 4-amino-2-chlorobenzotrifluoride (300 mg) and pyridine (243 mg) in dichloromethane (10 mL) was added a solution of trichloroacetyl chloride (279 mg) in dichloromethane (5 mL) dropwise. The solution was stirred for 2 hrs and then concentrated at reduced pressure. The residue was purified by silica gel chromatography eluting with 0-10% ethyl acetate in hexane to give the title compound as a white solid (360 mg, 69%).

後処理

  1. concentrationconcentrated at reduced pressure
  2. customThe residue was purified by silica gel chromatography
  3. washeluting with 0-10% ethyl acetate in hexane

出典と根拠

ORDレコード
ord-ada302043cf441feab5994ff6e306249
出典データセット
uspto-grants-2011_03
特許番号
US07906645B2

関連ノート

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