2-(tert-Butylamino)ethanol → 1-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-ol

HRID 603260

反応式

HRID 603260 の反応式
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:12][O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:13]([NH:17][CH2:18][CH2:19][OH:20])([CH3:16])([CH3:15])[CH3:14]>C(O)C>[CH2:1]([O:8][CH2:9][CH:10]([OH:11])[CH2:12][N:17]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:18][CH2:19][OH:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 783612-(tert-Butylamino)ethanolHCID 94247Benzyl glycidyl ether

生成物 1

HCID 576568621-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-ol収率 83.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-[(benzyloxy)methyl]oxirane (350 mg) and 2-(tert-butylamino)ethanol (500 mg) in ethanol (20 mL) was heated to reflux temperature and left at this temperature overnight. The solution was concentrated at reduced pressure. The residue was purified by filtration through a short pad of silica eluting with 20% methanol in dichloromethane. This gave the title compound as a colourless oil (501 mg)

後処理

  1. temperatureto reflux temperature
  2. concentrationThe solution was concentrated at reduced pressure
  3. filtrationThe residue was purified by filtration through a short pad of silica eluting with 20% methanol in dichloromethane

出典と根拠

ORDレコード
ord-006fedb16250481cbc8dc74c7ccb5e7b
出典データセット
uspto-grants-2011_03
特許番号
US07906645B2

関連ノート

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