Pyridine → N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide

HRID 60380

反応式

HRID 60380 の反応式
[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.N1C=CC=CC=1>O>[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][S:16]([C:13]2[CH:14]=[CH:15][C:10]([CH3:9])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 885792-Pyridinamine, 5-iodo-

生成物 1

HCID 21772024N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide収率 86.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 5-iodopyridin-2-amine (25.5 g), 4-methylbenzene-1-sulfonyl chloride (23.2 g) and pyridine (250 mL) was stirred at 100° C. overnight. The reaction mixture was poured into water (1.2 L) and stirred. The resulting solid was collected by filtration. The obtained solid was washed with water and diethyl ether and dried in vacuo to give the title compound (37.4 g) as a white solid.

後処理

  1. stirringstirred
  2. filtrationThe resulting solid was collected by filtration
  3. washThe obtained solid was washed with water and diethyl ether
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-2f3fa683d20e43d580c697040c92e7b9
出典データセット
uspto-grants-2016_09
特許番号
US09440987B2

関連ノート

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