Thionyl Chloride → 1-Bromo-2-(chloromethyl)-4,5-dimethoxybenzene
反応式
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH3:11])=[CH:4][C:3]=1[CH2:12]O.S(Cl)([Cl:16])=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH3:11])=[CH:4][C:3]=1[CH2:12][Cl:16]参加物
4
実験手順
(2-Bromo-4,5-dimethoxy-phenyl)-methanol (2.47 g) is dissolved in methylene chloride (30 ml) and thereto is added thionyl chloride (875 μl), and the mixture is stirred at room temperature for 30 minutes. The reaction solution is concentrated under reduced pressure, and thereto is added hexane and the resulting crystal is filtered to give 1-bromo-2-chloromethyl-4,5-dimethoxy-benzene (2.25 g). MS (m/z): 229/231
後処理
- concentrationThe reaction solution is concentrated under reduced pressure
- additionis added hexane
- filtrationthe resulting crystal is filtered
出典と根拠
- ORDレコード
- ord-7d6b77474a7641058318025df334334e
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07906517B2
反応ノート
読み込み中…