Thionyl Chloride → 4-Benzyloxy-2-chloromethyl-5'-isopropyl-2'-methoxy-biphenyl

HRID 604190ノート

反応式

HRID 604190 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([CH:21]([CH3:23])[CH3:22])[CH:18]=[CH:17][C:16]=2[O:24][CH3:25])=[C:11]([CH2:26]O)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:30])=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([CH:21]([CH3:23])[CH3:22])[CH:18]=[CH:17][C:16]=2[O:24][CH3:25])=[C:11]([CH2:26][Cl:30])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 67087233(4-Benzyloxy-5'-isopropyl-2'-methoxy-biphenyl-2-yl)-methanol

生成物 1

HCID 670872924-Benzyloxy-2-chloromethyl-5'-isopropyl-2'-methoxy-biphenyl

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(4-Benzyloxy-5′-isopropyl-2′-methoxy-biphenyl-2-yl)-methanol (1.10 g) is dissolved in methylene chloride (10 ml), and thereto is added thionyl chloride (332 μl) and the mixture is stirred at room temperature for 30 minutes. The reaction solution is concentrated under reduced pressure, and the residue is purified by silica gel column chromatography (hexane:ethyl acetate=1:0→9:1) to give 4-benzyloxy-2-chloromethyl-5′-isopropyl-2′-methoxy-biphenyl (1.15 g). MS (m/z): 345

後処理

  1. concentrationThe reaction solution is concentrated under reduced pressure
  2. customthe residue is purified by silica gel column chromatography (hexane:ethyl acetate=1:0→9:1)

出典と根拠

ORDレコード
ord-004fd657aba14ec68b3273ade9a48071
出典データセット
uspto-grants-2011_03
特許番号
US07906517B2

反応ノート

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