1,3-Dibromopropane → HCID 21883826、化合物
反応式
[Br:1][CH2:2][CH2:3][CH2:4]Br.C(=O)([O-])[O-].[K+].[K+].[CH:12]1([C:15]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:16])[CH2:14][CH2:13]1>CC(C)=O>[Br:1][CH2:2][CH2:3][CH2:4][O:23][C:20]1[CH:19]=[CH:18][C:17]([C:15]([CH:12]2[CH2:13][CH2:14]2)=[O:16])=[CH:22][CH:21]=1参加物
5
実験手順
To a stirred and heated mixture of 1,3-dibromopropane (5 mmol) and potassium carbonate (3.4 mmol) in acetone (40 ml) was added dropwise a solution of 4-cyclopropanecarbonylphenol (5 mmol) in acetone (20 ml). The reaction was allowed to continue overnight. The mixture was filtered hot and the solvent removed under reduced pressure to leave an oil. The oil was purified by column chromatography on silica gel eluting with petroleum ether/ethyl acetate (15:1).
後処理
- temperatureheated
- filtrationThe mixture was filtered hot
- customthe solvent removed under reduced pressure
- customto leave an oil
- customThe oil was purified by column chromatography on silica gel eluting with petroleum ether/ethyl acetate (15:1)
出典と根拠
- ORDレコード
- ord-c146b9d22db44e2baee94f459391687e
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07910605B2
反応ノート
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