Water → 2-amino-4-phenyl-1,3-thiazole-5-carbohydrazide

HRID 604491ノート

反応式

HRID 604491 の反応式
C([O:3][C:4]([C:6]1[S:10][C:9]([NH2:11])=[N:8][C:7]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)C.O.[NH2:19][NH2:20].O>CO>[NH2:11][C:9]1[S:10][C:6]([C:4]([NH:19][NH2:20])=[O:3])=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:8]=1

参加物

5

反応物 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)2 回HCID 73239Ethyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate

生成物 1

HCID 14819492-amino-4-phenyl-1,3-thiazole-5-carbohydrazide収率 70%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Amino-4-phenyl-thiazole-5-carboxylic acid ethyl ester (5.0 g, 20 mmol) was suspended in methanol. Hydrazine monohydrate (5 mL, 100 mmol) was added and heated to reflux for 2 h. Hydrazine monohydrate (10 mL) was added and heated to reflux for 48 h. Water (100 mL) was added to the reaction mixture and the methanol was removed by evaporation in vacuo. The product precipitates and the solid product is collected by filtration. Yield: 70%.

後処理

  1. temperatureheated
  2. temperatureto reflux for 2 h
  3. temperatureheated
  4. temperatureto reflux for 48 h
  5. customthe methanol was removed by evaporation in vacuo
  6. customThe product precipitates
  7. filtrationthe solid product is collected by filtration

出典と根拠

ORDレコード
ord-0bd77e4e343e477e91ed3a528e4aeb3c
出典データセット
uspto-grants-2011_03
特許番号
US07910613B2

反応ノート

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