Dimethylformamide → 3-Dimethylaminobenzoyl chloride hydrochloride
反応式
[CH3:1][N:2]([CH3:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](O)=[O:7].C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>ClC(Cl)C>[ClH:16].[CH3:1][N:2]([CH3:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([Cl:16])=[O:7]参加物
5
実験手順
To a solution of 3-(dimethylamino) benzoic acid (5.0 g. 30.0 mmol) in dichloroethane (50 mL) was added oxalyl chloride (5.6 g, 44.6 mmol) drop wise followed by catalytic amount of DMF. The reaction was stirred for 16 h. The excess oxalyl chloride and solvent were removed under reduced pressure. The residue was chased with benzene to give the desired product (6.1 g, 92%).
後処理
- customThe excess oxalyl chloride and solvent were removed under reduced pressure
出典と根拠
- ORDレコード
- ord-5d75a835a4854f5189d6479b84c00620
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07910595B2
反応ノート
読み込み中…