Hydrochloric Acid → 5-Chloro-4-nitrothiophene-2-carboxylic acid

HRID 605316ノート

反応式

HRID 605316 の反応式
C([O:3][C:4]([C:6]1[S:7][C:8]([Cl:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)=[O:5])C.[OH-].[Li+].Cl>CO.O>[Cl:14][C:8]1[S:7][C:6]([C:4]([OH:5])=[O:3])=[CH:10][C:9]=1[N+:11]([O-:13])=[O:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 56763846HCID 56763846、化合物

生成物 1

HCID 132055635-Chloro-4-nitrothiophene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

The product from Example 351A (1 equiv) was dissolved in a methanol/water 3/1 mixture followed by the addition of lithium hydroxide (5 equiv). The resultant solution was stirred at room temperature for 24 hours followed by the addition of 1N aqueous hydrochloric acid until the solution was a pH of 2. The mixture was then extracted with ethyl acetate, the organic extracts dried and concentrated under vacuum to provide the title product.

後処理

  1. extractionThe mixture was then extracted with ethyl acetate
  2. customthe organic extracts dried
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-8671b14d8ae14514951ecdd76cc41574
出典データセット
uspto-grants-2011_03
特許番号
US07910595B2

反応ノート

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