Potassium Iodide → 4-[(Ethylpropylamino)methyl]benzenemethanol

HRID 605579ノート

反応式

HRID 605579 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][CH:4]=1.[CH2:11]([NH:13][CH2:14][CH2:15][CH3:16])[CH3:12].[I-].[K+].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH2:11]([N:13]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][CH:4]=1)[CH2:14][CH2:15][CH3:16])[CH3:12]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 883981-Propanamine, N-ethyl-HCID 5107660[4-(Chloromethyl)phenyl]methanol

生成物 1

HCID 866357944-[(Ethylpropylamino)methyl]benzenemethanol収率 52.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 5 g of [4-(chloromethyl)phenyl]methanol, 5.56 g of N-ethylpropan-1-amine, 5.29 g of potassium iodide and 4.41 g of K2CO3 in 200 ml of acetonitrile is left to stir at AT for 48 hours. The reaction mixture is concentrated under vacuum, the residue is taken up with water, the mixture is extracted with DCM, the organic phase is dried over Na2SO4, and the solvent is evaporated off under vacuum. 3.5 g of the expected compound are obtained.

後処理

  1. waitis left
  2. concentrationThe reaction mixture is concentrated under vacuum
  3. extractionthe mixture is extracted with DCM
  4. dry with materialthe organic phase is dried over Na2SO4
  5. customthe solvent is evaporated off under vacuum

出典と根拠

ORDレコード
ord-c40dd9c3b98f4a65bbec09837094493d
出典データセット
uspto-grants-2011_03
特許番号
US07915258B2

反応ノート

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