Sodium Hydroxide → 1-Benzothiophene-7-carboxylic acid

HRID 605953ノート

反応式

HRID 605953 の反応式
C([O:3][C:4]([C:6]1[C:11]2[S:12][CH:13]=[CH:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+]>CO.O>[S:12]1[CH:13]=[CH:14][C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:11]1=2

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 49758023Ethyl benzo[b]thiophene-7-carboxylate

生成物 1

HCID 142350731-Benzothiophene-7-carboxylic acid収率 59%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of benzo[b]thiophene-7-carboxylic acid ethyl ester (1.0 g, 48 mmol) in methanol (10 mL) and water (10 mL) is added sodium hydroxide (5 g, excess). The solution is stirred at room temperature for 30 min; at which point all the ester has been consumed. The reaction mixture is adjusted to pH 1 by adding 6M HCl solution, and extracted with DCM. The combined organic layers are filtered through a silica plug to afford the title compound as a yellow solid (505.2 mg, 59%).

後処理

  1. customat which point all the ester has been consumed
  2. additionby adding 6M HCl solution
  3. extractionextracted with DCM
  4. filtrationThe combined organic layers are filtered through a silica plug

出典と根拠

ORDレコード
ord-d91cd1895e324c6aaf09b9b5c1880d06
出典データセット
uspto-grants-2011_03
特許番号
US07915256B2

反応ノート

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