Tetrahydrofuran → HCID 22248434、化合物

HRID 606178ノート

反応式

HRID 606178 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH2:22])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:23]1CC[CH2:25][CH2:24]1>C(OC(=O)C)(=O)C.C(N(CC)CC)C>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH:22][C:24](=[O:23])[CH3:25])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 22248383tert-Butyl 4-[(2-aminophenoxy)methyl]piperidine-1-carboxylate

生成物 1

HCID 22248434HCID 22248434、化合物収率 100%

試薬・触媒・溶媒 2

HCID 7918Acetic Anhydride溶媒HCID 8471Triethylamine溶媒

実験手順

After dissolving 400 mg of 1-(tert-butoxycarbonyl)-4-(2-aminophenoxymethyl)piperidine in 10 ml of tetrahydrofuran, 0.15 ml of acetic anhydride and 0.24 ml of triethylamine were added and the mixture was stirred overnight at room temperature. The reaction solution was filtered with silica gel and NH silica gel. The solvent was distilled off under reduced pressure to obtain the title compound (459 mg, 100% yield).

後処理

  1. additionwere added
  2. filtrationThe reaction solution was filtered with silica gel and NH silica gel
  3. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-fe2dd575ea5747998aea5892d2344a8a
出典データセット
uspto-grants-2011_03
特許番号
US07915274B2

反応ノート

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