Sodium borohydride → (5-(Furan-2-yl)-1,2-oxazol-3-yl)methanol
反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[O:8][N:7]=1)=O)C.[BH4-].[Na+]>C(O)C>[O:12]1[CH:13]=[CH:14][CH:15]=[C:11]1[C:9]1[O:8][N:7]=[C:6]([CH2:4][OH:3])[CH:10]=1参加物
4
実験手順
To a solution of 2.00 g of 5-furan-2-yl-isoxazole-3-carboxylic acid ethyl ester in absolute ethanol was slowly added 548 mg of sodiumborohydride at 0° C. After stirring at room temperature for 4 hrs, the reaction was quenched by addition of distilled water. The reaction solution was concentrated under reduced pressure and extracted with methylene chloride. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to produce 1.41 g of (5-furan-2-yl-isoxazol-3-yl)-methanol. (Yield 88%). This concentrate was used in the next step without further purification.
後処理
- customat 0° C
- customthe reaction was quenched by addition of distilled water
- concentrationThe reaction solution was concentrated under reduced pressure
- extractionextracted with methylene chloride
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-1cea36d8160c42ebaa3d9a4b5165e8e6
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915297B2
反応ノート
読み込み中…