Tert-butyl 2-(4-(benzyloxy)benzoyl)hydrazinecarboxylate → HCID 9813709、化合物

HRID 606328ノート

反応式

HRID 606328 の反応式
C([O:8][C:9]1[CH:25]=[CH:24][C:12]([C:13]([NH:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:14])=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.CO.C(Cl)Cl.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH:15][NH:16][C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])=[O:14])=[CH:24][CH:25]=1

参加物

6

反応物 1

HCID 66822257Tert-butyl 2-(4-(benzyloxy)benzoyl)hydrazinecarboxylate

生成物 1

HCID 9813709HCID 9813709、化合物収率 96%

試薬・触媒・溶媒 4

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of tert-butyl 2-[4-(benzyloxy)benzoyl]hydrazinecarboxylate (975 mg, 2.85 mmol) in presence of catalytic amount of Pd—C 10% in ethanol (40 mL) is hydrogenated for 3 hours. After filtration on celite, the residue is purified on column chromatography (silica gel, 10% MeOH in CH2Cl2) and tert-butyl 2-(4-hydroxybenzoyl)hydrazine carboxylate (0.688 g, yield: 96%) was identified by NMR spectroscopy.

後処理

  1. filtrationAfter filtration on celite

出典と根拠

ORDレコード
ord-e943e9bbf6de4899a5cb17917a1e3500
出典データセット
uspto-grants-2011_03
特許番号
US07915295B2

反応ノート

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