反応式
[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)=[O:3].CN(C=O)C.Br[C:17]1[CH:18]=[CH:19][C:20]([N+:23]([O-:25])=[O:24])=[N:21][CH:22]=1>>[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:17]2[CH:18]=[CH:19][C:20]([N+:23]([O-:25])=[O:24])=[N:21][CH:22]=2)=[CH:6][CH:5]=1)=[O:3]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 4-methanesulfinyl-phenol (1.52 g, 9.7 mmol) in DMF (30 ml) cesium carbonate (4.2 g, 12.9 mmol) was added, followed by addition of 5-bromo-2-nitro pyridine (1.75 g, 8.6 mmol) and the mixture was stirred at 50° C. over night. The suspension was filtered and evaporated+co-evaporated with toluene. The compound was purified by chromatography (0→10% EtOH in Methylene chloride) to give 1.5 g (56%) of 5-(4-Methanesulfinyl-phenoxy)-2-nitro-pyridine.
後処理
- filtrationThe suspension was filtered and evaporated+co-evaporated with toluene
- customThe compound was purified by chromatography (0→10% EtOH in Methylene chloride)
出典と根拠
- ORDレコード
- ord-7fe3a4269f3e4b128e11fe13bb3e7401
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915295B2
関連ノート
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