[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:4]([C:16]([NH2:18])=[O:17])[CH:3]=1.C1COCC1.CC[O-].[Na+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>C(O)C>[NH2:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[N:8]=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[NH:18][C:16]2=[O:17]To a solution of ethyl {[4-amino-2-(aminocarbonyl)phenyl]amino}(oxo)acetate (1.96 g) in a mixed solvent of THF (60 ml)-ethanol (30 mL) was added dropwise sodium ethylate (20% ethanol solution, 2.82 g), and the mixture was stirred at room temperature for 12 hr. 10% Aqueous citric acid solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried and concentrated, and the obtained crude crystals were washed with diisopropyl ether to give the title compound (738 mg).
読み込み中…
