Sodium Hydroxide → HCID 178493213、化合物

HRID 606706ノート

反応式

HRID 606706 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

参加物

4

反応物 2

HCID 14798Sodium Hydroxide2 回HCID 178493214Pantoprazole2 回

生成物 1

HCID 178493213HCID 178493213、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
2 °C

実験手順

A 100 ml round bottomed flask equipped with a magnetic stir bar was charged with acetone (50 ml). Pantoprazole (10 g, 25.7 mmol) was then added to the flask. After the pantoprazole had completely dissolved, the solution was cooled to about 2° C. Forty seven percent sodium hydroxide (aq.) equivalent to 2.4 grams of solid sodium hydroxide (60.0 mmol) was slowly added to the cooled solution. A precipitate began to form immediately. The mixture was stirred for another two hours while the flask was allowed to warm to room temperature. The precipitate was filtered and washed with acetone (20 ml) and dried at 40° C. under vacuum to yield pantoprazole sodium Form II (6.9 g, 65%).

後処理

  1. customA 100 ml round bottomed flask equipped with a magnetic stir bar
  2. customto form immediately
  3. temperatureto warm to room temperature
  4. filtrationThe precipitate was filtered
  5. washwashed with acetone (20 ml)
  6. customdried at 40° C. under vacuum

出典と根拠

ORDレコード
ord-dfc5a878725543229683d24c32db84a5
出典データセット
uspto-grants-2011_03
特許番号
US07915423B2

反応ノート

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