Sodium Hydroxide → HCID 178493213、化合物

HRID 606707ノート

反応式

HRID 606707 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178493214Pantoprazole

生成物 1

HCID 178493213HCID 178493213、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 100 ml flask was charged with toluene (50.0 ml). Pantoprazole (5.0 g, 12.8 mmol) and 47% aqueous NaOH (1.2 g) were added to the stirred solvent at room temperature. The mixture was stirred until dissolution and then overnight until precipitation. The solid was filtered giving pantoprazole sodium. The sample was dried at 45° C. under 10 mm Hg vacuum overnight, giving 4.21 g of amorphous pantoprazole sodium.

後処理

  1. customovernight until precipitation
  2. filtrationThe solid was filtered

出典と根拠

ORDレコード
ord-24d28905f6e740c4a9e934f355ac8919
出典データセット
uspto-grants-2011_03
特許番号
US07915423B2

反応ノート

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