Sodium Hydroxide → HCID 178493213、化合物

HRID 606708ノート

反応式

HRID 606708 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>C(O)CCC>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178493214Pantoprazole

生成物 1

HCID 178493213HCID 178493213、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

Pantoprazole (5.0 g, 12.8 mmol) and 98.5% NaOH (0.52 g, 12.8 mmol) were dissolved in 1-butanol (10.0 ml) at room temperature and the solution was stirred overnight at room temperature. The solution was cooled in a refrigerator and then stirred at room temperature until crystallization occurred. The crystals were filtered and dried at 50° C. under 10 mm Hg vacuum overnight to afford pantoprazole sodium Form V as determined by PXRD.

後処理

  1. temperatureThe solution was cooled in a refrigerator
  2. stirringstirred at room temperature until crystallization
  3. filtrationThe crystals were filtered
  4. customdried at 50° C. under 10 mm Hg vacuum overnight

出典と根拠

ORDレコード
ord-18190b89d1014058ab348118df0fa113
出典データセット
uspto-grants-2011_03
特許番号
US07915423B2

反応ノート

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