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Hydrochloric Acid → 3-Ethynylbenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-[(Trimethylsilyl)ethynyl]benzonitrile | HCID 22570318 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Ethynylbenzonitrile | HCID 12088964 | 92% |
反応手順
Add potassium carbonate (0.138 g, 1 mmol) to a solution of 3-trimethylsilanylethynylbenzonitrile from PREPARATION 5 (2.0 g, 10.1 mmol) in methanol (50 mL). Stir the mixture at room temperature for 20 min and add a 10% aqueous hydrochloric acid solution (4 mL). Concentrate to a reduced volume, add diethyl ether and water and separate the phases. Wash once the aqueous phase with diethyl ether. Combine the organic phases, dry over sodium sulfate and concentrate to obtain the title compound as a solid (1.17 g, 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07915424B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-0eabd544b1254993971a164e6b861429 |
| 出典メモ | uspto-grants-2011_03 |